Synthesis of biologically active derivatives of D-glucosamine-4-phosphate and 1-thyminyl-D-glucosamine-4,6-disulfate.
نویسندگان
چکیده
منابع مشابه
Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate.
Studies in viva on the biosynthesis of n-glucosamine, with the use of specifically labeled glucose in the rat (1,2) and in group A streptococci (3-5) showed that the glucose carbon chain was preserved during its conversion to the hexosamine. Leloir and Cardini (6, 7) noted that extracts obtained from Neurospora crassa converted glutamine and hexose phosphate to glutamic acid and a product tenta...
متن کاملSynthesis of dibekacin (3',4'-dideoxykanamycin B) from D-glucosamine and D-glucose.
(22), has been synthesized from D-glucosamine and D-glucose using an oxidative decarboxylation reaction with lead tetraacetate and a re-ductive deacetoxylation reaction with sodium borohydride as key-reactions. Using an oxidative decarboxylation reaction with lead tetraacetate and a reductive deacetoxylation reaction with sodium borohydride as key-reactions, we have been developing a versatile ...
متن کاملThe shape of D-glucosamine.
The bioactive amino monosaccharide D-glucosamine has been generated in the gas phase via laser ablation of D-glucosamine hydrochloride. Three cyclic α-(4)C1 pyranose forms have been identified using Fourier transform microwave techniques. Stereoelectronic hyperconjugative forces - essentially linked with the anomeric or gauche effect - and cooperative OH···O, OH···N and NH···O chains, extended ...
متن کاملMetabolism of D-Glucosamine and kketyl-D- glucosamine in the Intact Rat*
It has been demonstrated that n-glucosamine and N-acetyln-glucosamine are metabolized in animal tissues to n-fructose via phosphorylated intermediates (14). It has also been shown that n-glucose is converted to n-glucosamine and incorporated into glycoproteins and mucopolysaccharides (Pll), probably through formation of uridine diphosphate derivatives as intermediates (4). Little work has been ...
متن کاملMetabolism of D-glucosamine and N-acetyl-D-glucosamine in the intact rat.
It has been demonstrated that n-glucosamine and N-acetyln-glucosamine are metabolized in animal tissues to n-fructose via phosphorylated intermediates (14). It has also been shown that n-glucose is converted to n-glucosamine and incorporated into glycoproteins and mucopolysaccharides (Pll), probably through formation of uridine diphosphate derivatives as intermediates (4). Little work has been ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1990
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.38.1766